Constructing Self and World

Sam speaks with Shamil Chandaria, a philanthropist, serial entrepreneur, technologist, and researcher. They discuss the brain from first principles; Bayesian inference; hierarchical predictive processing; the construction of vision; psychedelics and neuroplasticity; beliefs and prior probabilities; the interaction between psychedelics and meditation; the risks and benefits of psychedelics; Sam’s recent experience with MDMA; non-duality; love, gratitude, and bliss; the self model; the Buddhist concept of emptiness; human flourishing; effective altruism; and other topics.